fntb farnesyltransferase, CAAX box, subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fntbprovided by ZNC
Official Full Name: farnesyltransferase, CAAX box, subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2220
See related: Ensembl:ENSDARG00000027916 AllianceGenome:ZFIN:ZDB-GENE-030131-2220
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86774; wu:fb99h09
Summary: Predicted to enable protein prenyltransferase activity and zinc ion binding activity. Predicted to contribute to protein farnesyltransferase activity. Acts upstream of or within cardiac ventricle development. Predicted to be part of protein farnesyltransferase complex. Is expressed in heart. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to several human genes including FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (28803982..28827760)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (28901106..28924877)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb99h09.x1 (e-PCR)
- UniSTS:192025

AI588368 (e-PCR)
- UniSTS:206200

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein farnesylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein farnesyltransferase subunit beta

Names: farnesyltransferase, CAAX box, beta

NP_001002128.1

EC 2.5.1.-

XP_021324041.1

EC 2.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002128.1 → NP_001002128.1 protein farnesyltransferase subunit beta

See identical proteins and their annotated locations for NP_001002128.1

Status: PROVISIONAL

Source sequence(s)

BC071443

UniProtKB/TrEMBL

A0A8M1N040, Q6IQG3

Related

ENSDARP00000034563.5, ENSDART00000038149.6

Conserved Domains (2) summary

PLN02710
Location:27 → 400

PLN02710; farnesyltranstransferase subunit beta

cd02893
Location:60 → 358

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

28803982..28827760

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468366.2 → XP_021324041.1 protein farnesyltransferase subunit beta isoform X1

UniProtKB/TrEMBL

A0A8M9PP61

Conserved Domains (1) summary

cd02893
Location:60 → 329

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...