pgrmc2 progesterone receptor membrane component 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pgrmc2provided by ZNC
Official Full Name: progesterone receptor membrane component 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2102
See related: Ensembl:ENSDARG00000030237 AllianceGenome:ZFIN:ZDB-GENE-040426-2102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56692; wu:fb25g12; wu:fd12f11
Summary: Acts upstream of or within oocyte maturation and ovulation. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; gonad; heart; integument; and muscle. Orthologous to human PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (26803470..26813490)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (26785079..26795099)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In addition to the delayed oocyte maturation and reduced female fertility, significant reduced ovulation was found in double knockout (pgrmc1/2(-/-)) in vivo, though not detected in either single knockout of Pgrmc (pgrmc1(-/-) or pgrmc2(-/-)).
Title: Downregulation of nuclear progestin receptor (Pgr) and subfertility in double knockouts of progestin receptor membrane component 1 (pgrmc1) and pgrmc2 in zebrafish.
a reduction in both spawning frequency and the number of embryos produced in female pgrmc2(-/-), was observed.
Title: Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fd12f11.x1 (e-PCR)
- UniSTS:195171

fc76b04.x1 (e-PCR)
- UniSTS:188262

fb25g12.x1 (e-PCR)
- UniSTS:190369

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: membrane-associated progesterone receptor component 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.