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    pcm1 pericentriolar material 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcm1provided by ZNC
    Official Full Name
    pericentriolar material 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-428
    See related
    Ensembl:ENSDARG00000062198 AllianceGenome:ZFIN:ZDB-GENE-030131-428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb30g01; wu:fb94e03; wu:fe14f07
    Summary
    Predicted to be involved in microtubule anchoring at centrosome; non-motile cilium assembly; and protein localization to centrosome. Predicted to act upstream of or within cilium assembly. Located in centrosome. Is expressed in head and post-vent region. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pcm1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (16621322..16654161)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (15928385..15961224)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 7b Neighboring gene microtubule associated tumor suppressor 1b Neighboring gene N-acylsphingosine amidohydrolase (acid ceramidase) 1b Neighboring gene uncharacterized LOC110439707

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Monroe TO, et al. Nat Commun, 2020 Nov 19. PMID 33214552, Free PMC Article
    2. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
    3. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV, et al. Dev Cell, 2008 Dec. PMID 19081074
    4. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476374, Free PMC Article
    5. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule anchoring at centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pericentriolar material 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115123.1 → NP_001108595.1  pericentriolar material 1 protein

      Status: PROVISIONAL

      Source sequence(s)
      AL935291
      UniProtKB/TrEMBL
      A0A8M1NI52, A0A8M9QB62
      Related
      ENSDARP00000136285.2, ENSDART00000164899.2
      Conserved Domains (1) summary
      pfam15717
      Location:1391 → 1989
      PCM1_C; Pericentriolar material 1 C terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      16621322..16654161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307141.3 → XP_009305416.1  pericentriolar material 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8M3B520, A0A8M9QAU8
      Conserved Domains (1) summary
      pfam15717
      Location:1437 → 2024
      PCM1_C; Pericentriolar material 1 C terminus

    2. XM_068223131.1 → XP_068079232.1  pericentriolar material 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9PSA8

    3. XM_068223196.1 → XP_068079297.1  pericentriolar material 1 protein isoform X6

      UniProtKB/TrEMBL
      A0A8M9QFV9

    4. XM_068223157.1 → XP_068079258.1  pericentriolar material 1 protein isoform X4

      UniProtKB/TrEMBL
      A0A8M9QJV5

    5. XM_009307146.3 → XP_009305421.1  pericentriolar material 1 protein isoform X3

      UniProtKB/TrEMBL
      A0A8M3AYV7, A0A8M9QFL3
      Conserved Domains (1) summary
      pfam15717
      Location:1426 → 2013
      PCM1_C; Pericentriolar material 1 C terminus

    6. XM_068223163.1 → XP_068079264.1  pericentriolar material 1 protein isoform X5

      UniProtKB/TrEMBL
      A0A8M9QB62
      Related
      ENSDARP00000124973.1, ENSDART00000149026.3

    7. XM_068223107.1 → XP_068079208.1  pericentriolar material 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8M3B520, A0A8M9QAU8

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394468.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      258827..289737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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