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    mdt-6 Mediator of RNA polymerase II transcription subunit 6 [ Caenorhabditis elegans ]

    Gene ID: 179091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdt-6
    Official Full Name
    Mediator of RNA polymerase II transcription subunit 6
    Primary source
    WormBase:WBGene00003164
    Locus tag
    CELE_Y57E12AL.5
    See related
    AllianceGenome:WB:WBGene00003164
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in excretory cell; intestine; and pharynx. Orthologous to human MED6 (mediator complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mdt-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (7058547..7059624, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF4148 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Serine incorporator 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans. Kwon JY, et al. FEBS Lett, 2001 Nov 23. PMID 11728440
    2. The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development. Kostrouchová M, et al. PeerJ, 2017. PMID 28603670, Free PMC Article
    3. The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. Taubert S, et al. PLoS Genet, 2008 Feb 29. PMID 18454197, Free PMC Article
    4. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
    5. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Yoda A, et al. Development, 2005 Apr. PMID 15790964

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mediator of RNA polymerase II transcription subunit 6
    NP_504791.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7058547..7059624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072390.7 → NP_504791.3  Mediator of RNA polymerase II transcription subunit 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504791.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18534, Q9N337
      Conserved Domains (1) summary
      pfam04934
      Location:19 → 149
      Med6; MED6 mediator sub complex component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N337.1

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