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    ppp1caa protein phosphatase 1, catalytic subunit, alpha isozyme a [ Danio rerio (zebrafish) ]

    Gene ID: 407980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp1caaprovided by ZNC
    Official Full Name
    protein phosphatase 1, catalytic subunit, alpha isozyme aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040516-3
    See related
    Ensembl:ENSDARG00000003486 AllianceGenome:ZFIN:ZDB-GENE-040516-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:85729; wu:fc04c08; wu:fc09b07; wu:fc30g11; wu:fe05h08
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within convergent extension. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; digestive system; eye; otic vesicle; and pectoral fin. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp1caa in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (30890427..30909484, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (30759585..30778642, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene lysine methyltransferase 5C Neighboring gene claudin i Neighboring gene coronin, actin binding protein, 1A Neighboring gene progestin and adipoQ receptor family member IVa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Shimizu N, et al. Cell Rep, 2014 Sep 11. PMID 25159144
    2. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. Yang BY, et al. Am J Physiol Endocrinol Metab, 2018 Jul 1. PMID 29351486
    3. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1, catalytic subunit, alpha isozyme a
    Names
    ppp1ca
    NP_999976.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214811.2 → NP_999976.1  protein phosphatase 1, catalytic subunit, alpha isozyme a

      See identical proteins and their annotated locations for NP_999976.1

      Status: VALIDATED

      Source sequence(s)
      BC070008, BX682556, CD758806
      UniProtKB/TrEMBL
      A8WGL7, F6P0B1, Q6NSN6
      Related
      ENSDARP00000002360.5, ENSDART00000025046.7
      Conserved Domains (1) summary
      cd07414
      Location:8 → 298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      30890427..30909484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394533.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      480356..499413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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