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    ktn1 kinectin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 368207, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ktn1provided by ZNC
    Official Full Name
    kinectin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030408-4
    See related
    Ensembl:ENSDARG00000032802 AllianceGenome:ZFIN:ZDB-GENE-030408-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb213; wu:fi20e02; wu:fi27f06
    Summary
    Predicted to enable kinesin binding activity. Predicted to act upstream of or within microtubule-based movement and protein transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alar plate midbrain region; eye; liver; midbrain; and musculature system. Orthologous to human KTN1 (kinectin 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ktn1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43926475..44002251)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43812710..43888486)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene amylase alpha 2A-like 1 Neighboring gene uncharacterized LOC137488139 Neighboring gene mutS homolog 4 Neighboring gene uncharacterized LOC100535512 Neighboring gene pellino E3 ubiquitin protein ligase family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Frese KS, et al. J Cell Sci, 2015 Aug 15. PMID 26116573, Free PMC Article
    2. Genome wide analysis reveals Zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. Winata CL, et al. PLoS Genet, 2013 Oct. PMID 24204288, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309329.1 → NP_001296258.1  kinectin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX465227, DY545513, EB897878, EB943723, EH489828
      UniProtKB/TrEMBL
      A0A8M1P1K0, E7F049
      Related
      ENSDARP00000107134.2, ENSDART00000121550.4
      Conserved Domains (1) summary
      pfam10174
      Location:462 → 1193
      Cast; RIM-binding protein of the cytomatrix active zone

    2. NM_200081.2 → NP_956375.2  kinectin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BX465227, DY545513, EB897878, EB943723, EH489828
      UniProtKB/TrEMBL
      A0A8N7UZY7, F1QJA1
      Related
      ENSDARP00000041446.6, ENSDART00000041447.7
      Conserved Domains (1) summary
      COG1196
      Location:384 → 1207
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      43926475..44002251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158886.3 → XP_005158943.1  kinectin isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5B8
      Related
      ENSDARP00000005691.10, ENSDART00000017376.10
      Conserved Domains (1) summary
      COG1196
      Location:384 → 1206
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_005158887.4 → XP_005158944.1  kinectin isoform X3

      UniProtKB/TrEMBL
      A0A8M2B5C3
      Conserved Domains (1) summary
      COG1196
      Location:384 → 1182
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_005158885.4 → XP_005158942.1  kinectin isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5E8
      Conserved Domains (2) summary
      pfam10174
      Location:461 → 1192
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16031
      Location:220 → 265
      TonB_N; TonB N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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