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    man2b2 mannosidase, alpha, class 2B, member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100003570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    man2b2provided by ZNC
    Official Full Name
    mannosidase, alpha, class 2B, member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-140106-166
    See related
    Ensembl:ENSDARG00000079463 AllianceGenome:ZFIN:ZDB-GENE-140106-166
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable alpha-mannosidase activity; carbohydrate binding activity; and metal ion binding activity. Predicted to act upstream of or within mannose metabolic process. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See man2b2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19509889..19526733, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19257947..19274765, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch211-212k18.8 Neighboring gene si:ch211-212k18.9 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene cyclin B1 interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Liver toxicity of macrolide antibiotics in zebrafish. Zhang MQ, et al. Toxicology, 2020 Aug. PMID 32454074
    2. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. Lorenzo-Orts L, et al. EMBO Rep, 2024 Jan. PMID 38177902, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epididymis-specific alpha-mannosidase
    Names
    zmp:0000001206
    XP_001337519.3
    XP_021333425.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      19509889..19526733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477750.2 → XP_021333425.1  epididymis-specific alpha-mannosidase

      UniProtKB/TrEMBL
      A0A8M1PZ41, A0A8M6Z1P3, E7F2X1
      Related
      ENSDARP00000099510.2, ENSDART00000114203.5
      Conserved Domains (2) summary
      PLN02701
      Location:20 → 1002
      PLN02701; alpha-mannosidase
      cl25404
      Location:23 → 348
      GH38-57_N_LamB_YdjC_SF; Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394683.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      232096..248940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001337483.7 → XP_001337519.3  epididymis-specific alpha-mannosidase

      UniProtKB/TrEMBL
      A0A8M1PZ41, A0A8M6Z1P3, E7F2X1
      Conserved Domains (2) summary
      PLN02701
      Location:20 → 1002
      PLN02701; alpha-mannosidase
      cl25404
      Location:23 → 348
      GH38-57_N_LamB_YdjC_SF; Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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