bmal2 basic helix-loop-helix ARNT like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmal2provided by ZNC
Official Full Name: basic helix-loop-helix ARNT like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000509-2
See related: Ensembl:ENSDARG00000041381 AllianceGenome:ZFIN:ZDB-GENE-000509-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: arntl2; wu:fj90c09
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and photoperiodism. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and type 2 diabetes mellitus. Orthologous to human BMAL2 (basic helix-loop-helix ARNT like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (15570910..15610484, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (15598251..15642213, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z6098 (e-PCR), detects polymorphism
- UniSTS:204856

fj90c09.x1 (e-PCR)
- UniSTS:200271

fj91c07.x1 (e-PCR)
- UniSTS:200302

G40403 (e-PCR)
- UniSTS:9426

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within photoperiodism	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to light stimulus	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aryl hydrocarbon receptor nuclear translocator-like protein 2

Names: aryl hydrocarbon receptor nuclear translocator-like 2; bmal2a; brain and muscle ARNT-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131578.2 → NP_571653.2 aryl hydrocarbon receptor nuclear translocator-like protein 2

Status: VALIDATED

Source sequence(s)

BX928740

UniProtKB/TrEMBL

A0A0R4IH97, A0A8M1PBM1, Q9IAU1

Related

ENSDARP00000134619.1, ENSDART00000099849.6

Conserved Domains (3) summary

cd00130
Location:172 → 266

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

cl25986
Location:353 → 456

PAS_3; PAS fold