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    nckap1 NCK-associated protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 561894, updated on 27-Dec-2024

    Summary

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    Official Symbol
    nckap1provided by ZNC
    Official Full Name
    NCK-associated protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4426
    See related
    Ensembl:ENSDARG00000060853 AllianceGenome:ZFIN:ZDB-GENE-030131-4426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd05c01; si:dkey-234n3.1
    Summary
    Acts upstream of or within heart development and neuron projection morphogenesis. Predicted to be located in lamellipodium membrane. Predicted to be part of SCAR complex. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nckap1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (44722205..44825419)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (44921239..45024467)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene dual specificity phosphatase 19a Neighboring gene uncharacterized LOC137496433 Neighboring gene frizzled related protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish. Biswas S, et al. Mol Biol Cell, 2014 Mar. PMID 24371087, Free PMC Article
    2. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
    3. Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Wang X, et al. Chemosphere, 2016 Feb. PMID 26595314
    4. CERKL knockdown causes retinal degeneration in zebrafish. Riera M, et al. PLoS One, 2013. PMID 23671706, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nck-associated protein 1
    Names
    NAP 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137665.1 → NP_001131137.1  nck-associated protein 1

      Status: PROVISIONAL

      Source sequence(s)
      BX548025, CR513785
      UniProtKB/TrEMBL
      A0A2U3TVM3, A0A8M1NLZ3
      Related
      ENSDARP00000080611.6, ENSDART00000086176.7
      Conserved Domains (1) summary
      pfam09735
      Location:13 → 1118
      Nckap1; Membrane-associated apoptosis protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      44722205..44825419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167921.5 → XP_005167978.1  nck-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8QPW3, A0A8M2BFC9
      Related
      ENSDARP00000156716.1, ENSDART00000190578.1
      Conserved Domains (1) summary
      pfam09735
      Location:13 → 1128
      Nckap1; Membrane-associated apoptosis protein

    2. XM_005167922.5 → XP_005167979.1  nck-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFE2
      Conserved Domains (1) summary
      pfam09735
      Location:13 → 1126
      Nckap1; Membrane-associated apoptosis protein

    3. XM_005167923.5 → XP_005167980.1  nck-associated protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005167980.1

      UniProtKB/Swiss-Prot
      B0S6R0, B0S6R1
      Related
      ENSDARP00000116328.1, ENSDART00000132696.2
      Conserved Domains (1) summary
      pfam09735
      Location:13 → 1122
      Nckap1; Membrane-associated apoptosis protein

    4. XM_005167924.5 → XP_005167981.1  nck-associated protein 1 isoform X4

      UniProtKB/Swiss-Prot
      B0S6R1
      Conserved Domains (1) summary
      pfam09735
      Location:13 → 1120
      Nckap1; Membrane-associated apoptosis protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0S6R1.1 GenPept UniProtKB/Swiss-Prot:B0S6R1

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