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    rbbp8 retinoblastoma binding protein 8 [ Danio rerio (zebrafish) ]

    Gene ID: 503536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbbp8provided by ZNC
    Official Full Name
    retinoblastoma binding protein 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050220-14
    See related
    Ensembl:ENSDARG00000043480 AllianceGenome:ZFIN:ZDB-GENE-050220-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:113143
    Summary
    Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing. Predicted to act upstream of or within DNA repair; cell division; and meiotic cell cycle. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rbbp8 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (36204117..36223956)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (36315941..36335873)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene PAK1 interacting protein 1 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene transmembrane protein 241 Neighboring gene RIO kinase 3 (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R, et al. Sci Adv, 2021 Jan. PMID 33514542, Free PMC Article
    2. Genetic control of cellular morphogenesis in Müller glia. Charlton-Perkins M, et al. Glia, 2019 Jul. PMID 30924555, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA endonuclease RBBP8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012500.1 → NP_001012518.1  DNA endonuclease RBBP8

      See identical proteins and their annotated locations for NP_001012518.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090186
      UniProtKB/Swiss-Prot
      F1R983
      Related
      ENSDARP00000063831.4, ENSDART00000063832.6
      Conserved Domains (2) summary
      pfam08573
      Location:549 → 609
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
      pfam10482
      Location:20 → 138
      CtIP_N; Tumour-suppressor protein CtIP N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      36204117..36223956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005174189.5 → XP_005174246.1  DNA endonuclease RBBP8 isoform X1

      See identical proteins and their annotated locations for XP_005174246.1

      UniProtKB/Swiss-Prot
      F1R983, Q5EAZ7
      Conserved Domains (2) summary
      pfam08573
      Location:549 → 609
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
      pfam10482
      Location:20 → 138
      CtIP_N; Tumour-suppressor protein CtIP N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1R983.1 GenPept UniProtKB/Swiss-Prot:F1R983

    Gene LinkOut

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