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    moag-4 Modifier of protein aggregation 4 [ Caenorhabditis elegans ]

    Gene ID: 171764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    moag-4
    Official Full Name
    Modifier of protein aggregation 4
    Primary source
    WormBase:WBGene00021348
    Locus tag
    CELE_Y37E3.4
    See related
    AllianceGenome:WB:WBGene00021348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in protein destabilization. Located in cytosol and nucleus. Orthologous to human SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See moag-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (2064976..2065481)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat protein 5 OB fold domain-containing protein Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC5 Neighboring gene ADP-ribosylation factor-like protein 13B Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein P1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SERF, a family of tiny highly conserved, highly charged proteins with enigmatic functions. Sahoo BR, et al. FEBS J, 2023 Sep. PMID 35694898
    2. MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions. Yoshimura Y, et al. J Biol Chem, 2017 May 19. PMID 28336532, Free PMC Article
    3. The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation. Pras A, et al. EMBO J, 2021 Nov 2. PMID 34617299, Free PMC Article
    4. Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity. van Ham TJ, et al. Cell, 2010 Aug 20. PMID 20723760
    5. The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis. Li Y, et al. J Cell Biol, 2010 Jun 14. PMID 20530210, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
      Title: The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
    2. NMR chemical shift perturbations demonstrate that a positively charged segment of MOAG-4 forms a transiently populated alpha-helix that interacts with the negatively charged C terminus of alpha-Syn.
      Title: MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.
    3. Study identifies an evolutionarily highly conserved modifier of aggregation, MOAG-4, as a positive regulator of aggregate formation in C. elegans models for polyglutamine diseases.
      Title: Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Modifier of protein aggregation 4
    NP_001380044.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2064976..2065481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393007.1 → NP_001380044.1  Modifier of protein aggregation 4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BKU8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BKU8.1

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