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    dbnlb drebrin-like b [ Danio rerio (zebrafish) ]

    Gene ID: 553729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dbnlbprovided by ZNC
    Official Full Name
    drebrin-like bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-293
    See related
    Ensembl:ENSDARG00000016016 AllianceGenome:ZFIN:ZDB-GENE-050522-293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dbnl; zgc:112450
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including positive regulation of neurogenesis; postsynaptic actin cytoskeleton organization; and regulation of actin filament polymerization. Predicted to be located in several cellular components, including cytoplasmic vesicle; perikaryon; and ruffle. Predicted to be active in several cellular components, including lamellipodium; postsynaptic density; and postsynaptic membrane. Predicted to colocalize with actin filament. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dbnlb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (52314598..52350358)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (52328037..52363829)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496394 Neighboring gene transcription factor 7 like 1b Neighboring gene ubiquitin conjugating enzyme E2 D4 Neighboring gene AT-rich interactive domain 5A Neighboring gene cytochrome c oxidase subunit 5Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
    2. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112450

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    drebrin-like b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020700.2 → NP_001018536.2  drebrin-like b

      Status: VALIDATED

      Source sequence(s)
      CABZ01070472, CN501129
      UniProtKB/TrEMBL
      A0A8M1N695, E7EXG2
      Related
      ENSDARP00000104897.2, ENSDART00000125241.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      52314598..52350358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167337.5 → XP_005167394.1  drebrin-like b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BEQ7, F1QIB3
      Related
      ENSDARP00000027911.8, ENSDART00000013059.9
      Conserved Domains (3) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:422 → 475
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl23720
      Location:182 → 243
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_021478260.2 → XP_021333935.1  drebrin-like b isoform X2

      UniProtKB/TrEMBL
      A0A8M9QIL1
      Conserved Domains (3) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:398 → 451
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      pfam07946
      Location:181 → 241
      DUF1682; Protein of unknown function (DUF1682)

    3. XM_005167339.5 → XP_005167396.1  drebrin-like b isoform X4

      UniProtKB/TrEMBL
      A0A8M2BEN5
      Conserved Domains (3) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:391 → 444
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl23720
      Location:182 → 243
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. XM_005167340.5 → XP_005167397.1  drebrin-like b isoform X5

      UniProtKB/TrEMBL
      A0A8M2BFE3
      Conserved Domains (3) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:367 → 420
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      cl23720
      Location:182 → 243
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. XM_005167338.5 → XP_005167395.1  drebrin-like b isoform X3

      UniProtKB/TrEMBL
      A0A8M2BES7
      Conserved Domains (4) summary
      cd11281
      Location:3 → 138
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
      cd11960
      Location:397 → 450
      SH3_Abp1_eu; Src homology 3 domain of eumetazoan Actin-binding protein 1
      pfam13892
      Location:163 → 223
      DBINO; DNA-binding domain
      cl05005
      Location:197 → 272
      TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    6. XM_068222958.1 → XP_068079059.1  drebrin-like b isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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