slc4a1a solute carrier family 4 member 1a (Diego blood group) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc4a1aprovided by ZNC
Official Full Name: solute carrier family 4 member 1a (Diego blood group)provided by ZNC
Primary source: ZFIN:ZDB-GENE-010525-1
See related: Ensembl:ENSDARG00000012881 AllianceGenome:ZFIN:ZDB-GENE-010525-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ae1; band3; slc4a1; zgc:111889; zgc:152771; si:dz180g5.1
Summary: Predicted to enable bicarbonate transmembrane transporter activity. Acts upstream of or within embryonic hemopoiesis; erythrocyte differentiation; and monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including erythroid lineage cell; hematopoietic system; liver; mesoderm; and pleuroperitoneal region. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (20065861..20091960, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (19916121..19942220, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis
Title: Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 4 member 1a (Diego blood group)

Names: AE1/band 3; erythroid anion exchanger 1; ret; retsina; solute carrier family 4 (anion exchanger), member 1a (Diego blood group); solute carrier family 4, anion exchanger, member 1; solute carrier family 4, anion exchanger, member 1a; zAE1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198338.1 → NP_938152.1 solute carrier family 4 member 1a (Diego blood group)

See identical proteins and their annotated locations for NP_938152.1

Status: PROVISIONAL

Source sequence(s)

AF350072

UniProtKB/TrEMBL

A0A8M1PF13, F1RAE7, Q7ZZJ7

Related

ENSDARP00000032458.4, ENSDART00000029386.7

Conserved Domains (3) summary

TIGR00834
Location:78 → 904

ae; anion exchange protein

pfam00955
Location:356 → 844

HCO3_cotransp; HCO3- transporter family

pfam07565
Location:106 → 309

Band_3_cyto; Band 3 cytoplasmic domain