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    cdca8 cell division cycle associated 8 [ Danio rerio (zebrafish) ]

    Gene ID: 492815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdca8provided by ZNC
    Official Full Name
    cell division cycle associated 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-171
    See related
    Ensembl:ENSDARG00000043137 AllianceGenome:ZFIN:ZDB-GENE-041114-171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb373; cdca8l; sb:cb373; zgc:101607
    Summary
    Acts upstream of or within heart development. Predicted to be located in several cellular components, including chromosome; cytoskeleton; and nucleus. Predicted to be part of chromosome passenger complex. Predicted to be active in chromosome, centromeric region and spindle midzone. Is expressed in proliferative region. Orthologous to human CDCA8 (cell division cycle associated 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cdca8 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (47773015..47782876, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48144919..48154856)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD94 Neighboring gene ephrin type-A receptor 7 Neighboring gene ribonucleotide reductase M2 polypeptide Neighboring gene claudin 35 Neighboring gene AFG2 interacting ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Sampath SC, et al. Cell, 2004 Jul 23. PMID 15260989
    2. Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Hsu AY, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31451657, Free PMC Article
    3. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, et al. Circulation, 2009 Aug 18. PMID 19652097, Free PMC Article
    4. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
    5. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    borealin
    Names
    Dasra B
    DrDasraB
    cell division cycle-associated protein 8
    dasra-B
    dasraB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007456.1 → NP_001007457.1  borealin

      See identical proteins and their annotated locations for NP_001007457.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085383
      UniProtKB/Swiss-Prot
      Q5U3V2, Q5XLR4
      UniProtKB/TrEMBL
      B2GQ71
      Related
      ENSDARP00000063336.6, ENSDART00000063337.8
      Conserved Domains (2) summary
      pfam10444
      Location:22 → 76
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:161 → 274
      Borealin; Cell division cycle-associated protein 8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      47773015..47782876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215121.1 → XP_068071222.1  borealin isoform X2

      UniProtKB/TrEMBL
      A0A8M6YUH5

    2. XM_017352229.3 → XP_017207718.1  borealin isoform X2

      UniProtKB/TrEMBL
      A0A8M6YUH5

    3. XM_005173787.5 → XP_005173844.1  borealin isoform X1

      UniProtKB/TrEMBL
      A0A8M2BL47, F1RBV2
      Conserved Domains (2) summary
      pfam10444
      Location:22 → 76
      Nbl1_Borealin_N; Nbl1 / Borealin N terminal
      pfam10512
      Location:161 → 274
      Borealin; Cell division cycle-associated protein 8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XLR4.2 GenPept UniProtKB/Swiss-Prot:Q5XLR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.