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    chia.6 chitinase, acidic.6 [ Danio rerio (zebrafish) ]

    Gene ID: 322420, updated on 27-Dec-2024

    Summary

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    Official Symbol
    chia.6provided by ZNC
    Official Full Name
    chitinase, acidic.6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1140
    See related
    Ensembl:ENSDARG00000093193 AllianceGenome:ZFIN:ZDB-GENE-030131-1140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:65788; wu:fb60f06
    Summary
    Predicted to enable chitin binding activity and chitinase activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in extracellular region. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chia.6 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17981218..17993667)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (18054875..18067324)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489113 Neighboring gene chitinase, acidic.5 Neighboring gene peptidase M20 domain containing 1, tandem duplicate 2 Neighboring gene peptidase M20 domain containing 1, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal expression patterns of chitinase genes in developing zebrafish embryos. Koch BE, et al. Gene Expr Patterns, 2014 Mar. PMID 24418193
    2. Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Meijer AH, et al. Mol Immunol, 2005 Jun. PMID 15829308
    3. Rearing Zebrafish on Black Soldier Fly (Hermetia illucens): Biometric, Histological, Spectroscopic, Biochemical, and Molecular Implications. Vargas A, et al. Zebrafish, 2018 Aug. PMID 29589997
    4. Partial Dietary Inclusion of Hermetia illucens (Black Soldier Fly) Full-Fat Prepupae in Zebrafish Feed: Biometric, Histological, Biochemical, and Molecular Implications. Zarantoniello M, et al. Zebrafish, 2018 Oct. PMID 29912648
    5. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Lelieveld LT, et al. J Lipid Res, 2022 May. PMID 35315333, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitinase, acidic.6
    NP_955897.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199603.2 → NP_955897.2  chitinase, acidic.6 precursor

      Status: VALIDATED

      Source sequence(s)
      CN509615, CR352232, EH449168
      UniProtKB/TrEMBL
      A0A8M1P9S1, F1QJL0
      Related
      ENSDARP00000018699.7, ENSDART00000012571.9
      Conserved Domains (3) summary
      cd02872
      Location:23 → 385
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:22 → 363
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:433 → 479
      CBM_14; Chitin binding Peritrophin-A domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      17981218..17993667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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