polg polymerase (DNA directed), gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: polgprovided by ZNC
Official Full Name: polymerase (DNA directed), gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060303-1
See related: Ensembl:ENSDARG00000060951 AllianceGenome:ZFIN:ZDB-GENE-060303-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable 3'-5' exonuclease activity and DNA-directed DNA polymerase activity. Predicted to be involved in mitochondrial DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in mitochondrial nucleoid. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; eye; fin; heart; and muscle. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (8478850..8513291, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (8401791..8436210, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial DNA replication	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of gamma DNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA polymerase subunit gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

8478850..8513291 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068217496.1 → XP_068073597.1 DNA polymerase subunit gamma-1 isoform X2
XM_001921095.7 → XP_001921130.3 DNA polymerase subunit gamma-1 isoform X1

UniProtKB/TrEMBL

A0A8M1QHI8, F8W5R6

Related

ENSDARP00000125000.1, ENSDART00000150129.3

Conserved Domains (4) summary

cd08641
Location:741 → 1167

DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria

pfam08597
Location:445 → 521

eIF3_subunit; Translation initiation factor eIF3 subunit

cl02626
Location:400 → 442

DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication

cl10012
Location:230 → 266

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
XM_068217497.1 → XP_068073598.1 DNA polymerase subunit gamma-1 isoform X3