lama4 laminin, alpha 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lama4provided by ZNC
Official Full Name: laminin, alpha 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-213
See related: Ensembl:ENSDARG00000020785 AllianceGenome:ZFIN:ZDB-GENE-040724-213
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-119m7.3; si:busm1-189a20.2
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including endothelial cell development; muscle attachment; and notochord development. Predicted to be located in extracellular region and membrane. Predicted to be active in basement membrane. Is expressed in several structures, including cardiovascular system; head; mesoderm; pectoral fin; and trunk musculature. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (218886..259965)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (230251..271330)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Lama4 in zebrafish resulted inthe same kind of cardiac dysfunction & hemorrhages seen in Ilk mutants. There is epistatic regulation between laminin-alpha4 (Lama4), integrin, and Ilk.
Title: Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of embryonic development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: laminin subunit alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039065.2 → NP_001034154.1 laminin subunit alpha-4 precursor

See identical proteins and their annotated locations for NP_001034154.1

Status: PROVISIONAL

Source sequence(s)

AY862414

UniProtKB/TrEMBL

Q2TJF5

Related

ENSDARP00000006065.7, ENSDART00000002661.8

Conserved Domains (7) summary

smart00180
Location:209 → 247

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:155 → 207

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1535 → 1672

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:99 → 152

Laminin_EGF; Laminin EGF domain

pfam06008
Location:351 → 611

Laminin_I; Laminin Domain I

pfam06009
Location:790 → 919

Laminin_II; Laminin Domain II

cl02488
Location:474 → 665

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...