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    nsun3 NOP2/Sun RNA methyltransferase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 553534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nsun3provided by ZNC
    Official Full Name
    NOP2/Sun RNA methyltransferase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050706-95
    See related
    Ensembl:ENSDARG00000013023 AllianceGenome:ZFIN:ZDB-GENE-050706-95
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7142194; zgc:109983
    Summary
    Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation; regulation of mitochondrial translation; and tRNA wobble base cytosine methylation. Predicted to act upstream of or within RNA methylation. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 48. Orthologous to human NSUN3 (NOP2/Sun RNA methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nsun3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (33697184..33722780)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (32964490..32989914)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 654 Neighboring gene claudin g Neighboring gene ADP-ribosylation factor-like 13b Neighboring gene uncharacterized LOC137490021 Neighboring gene eph receptor A6 Neighboring gene microRNA 734

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Shi W, et al. J Immunol, 2019 Nov 1. PMID 31562209
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109983

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble base cytosine methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
    Names
    NOL1/NOP2/Sun domain family, member 3
    NOP2/Sun domain family, member 3
    putative methyltransferase NSUN3
    NP_001020473.2
    NP_001418011.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025302.2 → NP_001020473.2  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR762462, CU915566
      UniProtKB/Swiss-Prot
      F6NJM6, Q4KMK0, Q6DG64
      Related
      ENSDARP00000118143.2, ENSDART00000131664.3

    2. NM_001431082.1 → NP_001418011.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR762462, CU915566
      UniProtKB/Swiss-Prot
      F6NJM6, Q4KMK0, Q6DG64
      UniProtKB/TrEMBL
      A0A8M2B6P7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      33697184..33722780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KMK0.2 GenPept UniProtKB/Swiss-Prot:Q4KMK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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