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    fcho2 FCH and mu domain containing endocytic adaptor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fcho2provided by ZNC
    Official Full Name
    FCH and mu domain containing endocytic adaptor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-228
    See related
    Ensembl:ENSDARG00000035389 AllianceGenome:ZFIN:ZDB-GENE-050522-228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb304; sb:cb304; wu:fa01a02; zgc:112167; si:ch211-195c22.1
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity and phosphatidylserine binding activity. Acts upstream of or within chordate embryonic development and convergent extension involved in axis elongation. Predicted to be located in membrane. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Is expressed in anterior axial hypoblast; hatching gland; immature eye; polster; and yolk syncytial layer. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fcho2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (35123662..35200779, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (34523509..34600720, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495519 Neighboring gene transmembrane protein 174 Neighboring gene transportin 1 Neighboring gene transfer RNA lysine (anticodon CUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Ramesh ST, et al. Traffic, 2021 Nov. PMID 34480404
    2. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112167

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within convergent extension involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane invagination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    F-BAR domain only protein 2
    Names
    FCH domain only 2
    FCH domain only protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020781.2 → NP_001018617.2  F-BAR domain only protein 2

      Status: VALIDATED

      Source sequence(s)
      CR377210, CR751565
      UniProtKB/Swiss-Prot
      Q502I9
      Related
      ENSDARP00000051270.5, ENSDART00000051271.7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      35123662..35200779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221192.1 → XP_068077293.1  F-BAR domain only protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PK46

    2. XM_068221199.1 → XP_068077300.1  F-BAR domain only protein 2 isoform X12

      UniProtKB/Swiss-Prot
      Q502I9
      Related
      ENSDARP00000141294.2, ENSDART00000166272.2

    3. XM_068221191.1 → XP_068077292.1  F-BAR domain only protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q8L9

    4. XM_068221197.1 → XP_068077298.1  F-BAR domain only protein 2 isoform X10

      UniProtKB/Swiss-Prot
      Q502I9
      UniProtKB/TrEMBL
      A0A8M9Q3B6

    5. XM_068221190.1 → XP_068077291.1  F-BAR domain only protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PK46

    6. XM_068221198.1 → XP_068077299.1  F-BAR domain only protein 2 isoform X11

      UniProtKB/Swiss-Prot
      Q502I9
      UniProtKB/TrEMBL
      A0A8M3B9M8

    7. XM_068221196.1 → XP_068077297.1  F-BAR domain only protein 2 isoform X9

      UniProtKB/Swiss-Prot
      Q502I9
      UniProtKB/TrEMBL
      A0A8M3ASB7

    8. XM_068221195.1 → XP_068077296.1  F-BAR domain only protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8M2BJ82, A0A8M3AZM0

    9. XM_068221194.1 → XP_068077295.1  F-BAR domain only protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8M2BJ82, A0A8M3B2H5

    10. XM_068221189.1 → XP_068077290.1  F-BAR domain only protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q8L9, A0A8M9QDY0

    11. XM_068221193.1 → XP_068077294.1  F-BAR domain only protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PXK6

    12. XM_068221188.1 → XP_068077289.1  F-BAR domain only protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q8L9

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394591.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      1241..38468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q502I9.1 GenPept UniProtKB/Swiss-Prot:Q502I9

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