met MET proto-oncogene, receptor tyrosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: metprovided by ZNC
Official Full Name: MET proto-oncogene, receptor tyrosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-1
See related: Ensembl:ENSDARG00000070903 AllianceGenome:ZFIN:ZDB-GENE-041014-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: don; cmet; c-met
Summary: Predicted to enable hepatocyte growth factor receptor activity. Acts upstream of or within several processes, including exocrine pancreas development; nervous system development; and pectoral fin development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (18583755..18681721)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (18487340..18583219)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion.
Title: Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion.
Results demonstrate a novel role of Klf8, achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos
Title: Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development.
Altogether, these results reveal a novel and essential role for HGF signaling in the intrapancreatic ducts during exocrine morphogenesis.
Title: Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis.
Results describe roles for Met signaling in coordinating growth and cell type specification within the developing cerebellum, and in migration of hindbrain neurons.
Title: The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration.
suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish
Title: Hgf/c-met expression and functional analysis during zebrafish embryogenesis.
Met is necessary for normal development of zebrafish primary and secondary motoneurons
Title: The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter.
Loss-of-function experiments reveal that Met and its ligand, hepatocyte growth factor, are required for the correct morphogenesis of the hypaxial muscles in which met is expressed.
Title: Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish.
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
Title: Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pancreas development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hepatocyte growth factor receptor

Names: met proto-oncogene (hepatocyte growth factor receptor)

NP_001007125.1

EC 2.7.10.1

XP_005163051.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007124.1 → NP_001007125.1 hepatocyte growth factor receptor

See identical proteins and their annotated locations for NP_001007125.1

Status: PROVISIONAL

Source sequence(s)

AY687384

UniProtKB/TrEMBL

A0A8M2BA12, Q64GK4

Related

ENSDARP00000152967.1, ENSDART00000180287.1

Conserved Domains (6) summary

cd11248
Location:43 → 511

Sema_MET_like; The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases

smart00423
Location:514 → 559

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:654 → 736

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1083 → 1344

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam07714
Location:1079 → 1338

Pkinase_Tyr; Protein tyrosine kinase

cl15674
Location:562 → 653

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

18583755..18681721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162994.5 → XP_005163051.1 hepatocyte growth factor receptor isoform X1

UniProtKB/TrEMBL

A0A8M2B9Z7, A0A8M2BA12, F1QLR7

Related

ENSDARP00000123904.1, ENSDART00000148741.2

Conserved Domains (6) summary

cd11248
Location:43 → 511

Sema_MET_like; The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases

smart00423
Location:514 → 559

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:654 → 736

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1083 → 1344

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam07714
Location:1079 → 1338

Pkinase_Tyr; Protein tyrosine kinase

cl15674
Location:562 → 653

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...