cbd-1 Chitin-binding domain protein cbd-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cbd-1
Official Full Name: Chitin-binding domain protein cbd-1
Primary source: WormBase:WBGene00010351
Locus tag: CELE_H02I12.1
See related: AllianceGenome:WB:WBGene00010351
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chitin binding activity. Involved in eggshell formation; positive regulation of protein localization to cell cortex; and positive regulation of protein localization to plasma membrane. Located in cell periphery. Is expressed in germ line and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cbd-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (11372991..11377627)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors found the PERM complex and EGG complex to be functionally independent, and structurally organized through distinct domains of CBD-1. CBD-1 is thus a multifaceted regulator that promotes distinct aspects of vitelline layer assembly and egg activation.
Title: CBD-1 organizes two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H02I12.1 (e-PCR)
- UniSTS:307737

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Chitin-binding domain protein cbd-1

NP_502145.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11372991..11377627

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069744.8 → NP_502145.2 Chitin-binding domain protein cbd-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502145.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O45599

Conserved Domains (2) summary

smart00494
Location:191 → 237

ChtBD2; Chitin-binding domain type 2

pfam01607
Location:1251 → 1296

CBM_14; Chitin binding Peritrophin-A domain