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    ints5 integrator complex subunit 5 [ Danio rerio (zebrafish) ]

    Gene ID: 564642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints5provided by ZNC
    Official Full Name
    integrator complex subunit 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090908-2
    See related
    Ensembl:ENSDARG00000077943 AllianceGenome:ZFIN:ZDB-GENE-090908-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within regulation of RNA splicing. Predicted to be part of integrator complex. Orthologous to human INTS5 (integrator complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ints5 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (45551979..45558651, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (46565256..46571390, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-114c17.1 Neighboring gene glucosidase II alpha subunit b Neighboring gene retinoic acid receptor responder 3 Neighboring gene retinoic acid receptor responder 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Tao S, et al. Development, 2009 Aug. PMID 19605500
    2. Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. Madera D, et al. Int J Mol Sci, 2023 Dec 19. PMID 38203224, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 5
    Names
    zmp:0000001187

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      45551979..45558651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_687970.8 → XP_693062.2  integrator complex subunit 5

      UniProtKB/TrEMBL
      A0A0R4IY96, A0A8N7TB96
      Related
      ENSDARP00000141758.1, ENSDART00000165060.2
      Conserved Domains (2) summary
      pfam14837
      Location:26 → 243
      INTS5_N; Integrator complex subunit 5 N-terminus
      pfam14838
      Location:266 → 1014
      INTS5_C; Integrator complex subunit 5 C-terminus
    Nucleotide Protein
    Heading Accession and Version

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