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    cep162 centrosomal protein 162 [ Danio rerio (zebrafish) ]

    Gene ID: 562035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cep162provided by ZNC
    Official Full Name
    centrosomal protein 162provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100922-266
    See related
    Ensembl:ENSDARG00000087369 AllianceGenome:ZFIN:ZDB-GENE-100922-266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-198c19.2
    Summary
    Involved in cilium assembly. Acts upstream of or within heart looping. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton and nucleoplasm. Is expressed in head. Orthologous to human CEP162 (centrosomal protein 162). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cep162 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (37891782..37944483)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (37941752..37994457)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487948 Neighboring gene si:ch211-198c19.1 Neighboring gene si:ch211-198c19.3 Neighboring gene melanocortin 2 receptor accessory protein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Wang WJ, et al. Nat Cell Biol, 2013 Jun. PMID 23644468, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 162 kDa
    Names
    protein QN1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353863.1 → NP_001340792.1  centrosomal protein of 162 kDa

      Status: VALIDATED

      Source sequence(s)
      BX088579
      UniProtKB/Swiss-Prot
      E7F5E1
      UniProtKB/TrEMBL
      A0A8M9PDT4
      Related
      ENSDARP00000121710.1, ENSDART00000142104.2
      Conserved Domains (3) summary
      cl25732
      Location:574 → 1332
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:428 → 517
      DUF4045; Domain of unknown function (DUF4045)
      cl28033
      Location:202 → 488
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      37891782..37944483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213979.1 → XP_068070080.1  centrosomal protein of 162 kDa isoform X1

    2. XM_068213980.1 → XP_068070081.1  centrosomal protein of 162 kDa isoform X2

    3. XM_068213981.1 → XP_068070082.1  centrosomal protein of 162 kDa isoform X3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394968.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      162550..214689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E7F5E1.1 GenPept UniProtKB/Swiss-Prot:E7F5E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.