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    bmp2k BMP2 inducible kinase [ Danio rerio (zebrafish) ]

    Gene ID: 494101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bmp2kprovided by ZNC
    Official Full Name
    BMP2 inducible kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-72
    See related
    Ensembl:ENSDARG00000020009 AllianceGenome:ZFIN:ZDB-GENE-041212-72
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101641
    Summary
    Predicted to enable AP-2 adaptor complex binding activity; phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway; regulation of bone mineralization; and regulation of clathrin-dependent endocytosis. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bmp2k in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (39099017..39152767)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (38498461..38552618)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene annexin A3a Neighboring gene progestin and adipoQ receptor family member IIIa Neighboring gene uncharacterized LOC137495613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Ramesh ST, et al. Traffic, 2021 Nov. PMID 34480404
    2. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BMP-2-inducible protein kinase
    NP_001008644.2
    NP_001180469.1
    XP_005165360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008644.2 → NP_001008644.2  BMP-2-inducible protein kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BX640536
      UniProtKB/TrEMBL
      A0A8M1N3L3, A2BHM9
      Related
      ENSDARP00000018789.8, ENSDART00000006079.10
      Conserved Domains (2) summary
      smart00220
      Location:41 → 300
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:36 → 309
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases

    2. NM_001193540.1 → NP_001180469.1  BMP-2-inducible protein kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX640536
      UniProtKB/TrEMBL
      A0A0R4IUS2, A0A8M1NX70
      Related
      ENSDARP00000140859.1, ENSDART00000166657.2
      Conserved Domains (3) summary
      smart00220
      Location:41 → 300
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:36 → 309
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:828 → 1081
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      39099017..39152767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165303.5 → XP_005165360.1  BMP-2-inducible protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCK0
      Conserved Domains (3) summary
      smart00220
      Location:41 → 300
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14037
      Location:36 → 309
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
      pfam15282
      Location:827 → 1080
      BMP2K_C; BMP-2-inducible protein kinase C-terminus

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394598.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      436789..501728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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