metap2b methionyl aminopeptidase 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: metap2bprovided by ZNC
Official Full Name: methionyl aminopeptidase 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2172
See related: Ensembl:ENSDARG00000102571 AllianceGenome:ZFIN:ZDB-GENE-030131-2172
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: metap2; zgc:66250; wu:fb98h06
Summary: Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Acts upstream of or within Wnt signaling pathway; definitive hemopoiesis; and hematopoietic stem cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; pronephric duct; and trunk. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (3231821..3246768)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (3106077..3121024)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated a hitherto-undescribed role of MetAP2 in definitive hematopoiesis and a possible link to noncanonical Wnt and ERK signaling.
Title: Methionine aminopeptidase 2 is required for HSC initiation and proliferation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloexopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloexopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid modification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-methionine modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: methionine aminopeptidase 2b

Names: methionine aminopeptidase 2; methionyl aminopeptidase 2

NP_955934.1

EC 3.4.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199640.1 → NP_955934.1 methionine aminopeptidase 2b

See identical proteins and their annotated locations for NP_955934.1

Status: PROVISIONAL

Source sequence(s)

BC055563

UniProtKB/TrEMBL

Q7SXK1

Related

ENSDARP00000139312.1, ENSDART00000163647.2

Conserved Domains (2) summary

cd01088
Location:164 → 472

MetAP2; Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

PTZ00053
Location:110 → 476

PTZ00053; methionine aminopeptidase 2; Provisional