mapk3 mitogen-activated protein kinase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mapk3provided by ZNC
Official Full Name: mitogen-activated protein kinase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040121-1
See related: Ensembl:ENSDARG00000070573 AllianceGenome:ZFIN:ZDB-GENE-040121-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ERK1; zERK1; fi06b09; wu:fi06b09
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including central nervous system development; cranial skeletal system development; and eye development. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cranium; digestive system; and heart. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (26211974..26222308, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (26081103..26091437, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAPK3 role in the oocyte maturation
Title: Relative importance of phosphatidylinositol-3 kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK3/1) signaling during maturational steroid-induced meiotic G2-M1 transition in zebrafish oocytes.
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
Title: ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
Data define distinct roles for ERK1 and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Title: Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.
eena plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 pathway
Title: eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish.
These results demonstrate that induction of Hsp70 in response to heat stress is dependent on ERK activation in Pac2 cells.
Title: Heat stress-induced heat shock protein 70 expression is dependent on ERK activation in zebrafish (Danio rerio) cells.
ERK1 and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
Title: ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of organelle organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 3

NP_958915.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201507.1 → NP_958915.1 mitogen-activated protein kinase 3

See identical proteins and their annotated locations for NP_958915.1

Status: PROVISIONAL

Source sequence(s)

BC045505

UniProtKB/TrEMBL

B2GNH0, Q7ZVK8

Related

ENSDARP00000094521.4, ENSDART00000103746.6

Conserved Domains (2) summary

smart00220
Location:56 → 344

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07849
Location:50 → 384

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases