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    igfals insulin-like growth factor binding protein, acid labile subunit [ Danio rerio (zebrafish) ]

    Gene ID: 570758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    igfalsprovided by ZNC
    Official Full Name
    insulin-like growth factor binding protein, acid labile subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061009-25
    See related
    Ensembl:ENSDARG00000037836 AllianceGenome:ZFIN:ZDB-GENE-061009-25
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-66h3.1
    Summary
    Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in brain; digestive system; heart; muscle; and pleuroperitoneal region. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See igfals in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (45845786..45848295, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (47893452..47895928, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 8 Neighboring gene unk like zinc finger Neighboring gene shisa family member 9b Neighboring gene uncharacterized LOC137490752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of acid-labile subunit (ALS) in developing and adult zebrafish and its role in dorso-ventral patterning during development. Landi E, et al. Gen Comp Endocrinol, 2020 Dec 1. PMID 32828812
    2. An in vivo functional assay to characterize human STAT5B genetic variants during zebrafish development. Landi E, et al. Hum Mol Genet, 2023 Jul 20. PMID 37162340
    3. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Knuth MM, et al. Sci Rep, 2020 Sep 29. PMID 32994480, Free PMC Article
    4. [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Fei F, et al. Sheng Li Xue Bao, 2017 Feb 25. PMID 28217809
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables insulin-like growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of insulin-like growth factor ternary complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein complex acid labile subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      45845786..45848295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003198155.6 → XP_003198203.1  insulin-like growth factor-binding protein complex acid labile subunit

      UniProtKB/TrEMBL
      A0A8M1RSH4, E9QJJ1, F1R1F2
      Related
      ENSDARP00000122885.1, ENSDART00000147198.2
      Conserved Domains (4) summary
      cd00116
      Location:219 → 456
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:108 → 131
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:48 → 81
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:227 → 286
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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