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    pcnp PEST proteolytic signal containing nuclear protein [ Danio rerio (zebrafish) ]

    Gene ID: 450014, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pcnpprovided by ZNC
    Official Full Name
    PEST proteolytic signal containing nuclear proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-130
    See related
    Ensembl:ENSDARG00000037713 AllianceGenome:ZFIN:ZDB-GENE-041010-130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:103440
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be active in nucleus. Orthologous to human PCNP (PEST proteolytic signal containing nuclear protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pcnp in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (7556965..7561222)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (6873532..6877793)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene LanC antibiotic synthetase component C-like 1 (bacterial) Neighboring gene myosin, light polypeptide 3, skeletal muscle Neighboring gene myxovirus (influenza) resistance A Neighboring gene myxovirus (influenza) resistance B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer. Maradonna F, et al. Cell Death Dis, 2022 Dec 23. PMID 36564370, Free PMC Article
    2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PEST proteolytic signal-containing nuclear protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006035.2 → NP_001006035.1  PEST proteolytic signal-containing nuclear protein isoform d

      See identical proteins and their annotated locations for NP_001006035.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      CT998565
      UniProtKB/TrEMBL
      A0A8M1P2X1, Q5XJC4
      Related
      ENSDARP00000054924.5, ENSDART00000054925.7
      Conserved Domains (1) summary
      pfam15473
      Location:1 → 101
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    2. NM_001326716.1 → NP_001313645.1  PEST proteolytic signal-containing nuclear protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      CT998565
      UniProtKB/TrEMBL
      A0A8M1P872, A0A8M9PPJ7, B8JKI0
      Related
      ENSDARP00000113543.1, ENSDART00000146682.3

    3. NM_001326717.1 → NP_001313646.1  PEST proteolytic signal-containing nuclear protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      CT998565
      UniProtKB/TrEMBL
      A0A2R8QL91, A0A8M1P3M7, A0A8M9PPJ7
      Related
      ENSDARP00000153830.1, ENSDART00000184465.1
      Conserved Domains (1) summary
      pfam15473
      Location:19 → 163
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    4. NM_001326718.1 → NP_001313647.1  PEST proteolytic signal-containing nuclear protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      CT998565
      UniProtKB/TrEMBL
      A0A8M1P8Y0, A0A8M9PPJ7, B8JKH9
      Related
      ENSDARP00000092359.4, ENSDART00000101586.6
      Conserved Domains (1) summary
      pfam15473
      Location:18 → 162
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    5. NM_001326719.1 → NP_001313648.1  PEST proteolytic signal-containing nuclear protein isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      CT998565
      UniProtKB/TrEMBL
      A0A8M1P2X1, Q5XJC4
      Related
      ENSDARP00000113454.1, ENSDART00000140189.3
      Conserved Domains (1) summary
      pfam15473
      Location:1 → 101
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      7556965..7561222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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