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    psmb10 proteasome 20S subunit beta 10 [ Danio rerio (zebrafish) ]

    Gene ID: 436816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmb10provided by ZNC
    Official Full Name
    proteasome 20S subunit beta 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-278
    See related
    Ensembl:ENSDARG00000043781 AllianceGenome:ZFIN:ZDB-GENE-040718-278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    beta2i; zgc:92791
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See psmb10 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77207693..77218584, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (75630955..75651464, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 585A-like Neighboring gene oocyte zinc finger protein XlCOF6-like Neighboring gene zinc finger protein 239-like Neighboring gene NLR family CARD domain-containing protein 3-like Neighboring gene si:dkey-172k15.13 Neighboring gene si:dkey-172k15.5 Neighboring gene zgc:174310

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. McConnell SC, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27493218, Free PMC Article
    2. Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. Grimholt U. BMC Evol Biol, 2018 Feb 23. PMID 29471808, Free PMC Article
    3. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Chernyavskaya Y, et al. Development, 2017 Aug 15. PMID 28698226, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proteasome subunit beta type-10
    Names
    proteasome subunit beta 10
    NP_001002543.2
    NP_001315481.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002543.2 → NP_001002543.2  proteasome subunit beta type-10

      Status: VALIDATED

      Source sequence(s)
      CU467646
      UniProtKB/TrEMBL
      A0A8M1PA63, F1QR78
      Related
      ENSDARP00000090716.2, ENSDART00000099943.5
      Conserved Domains (3) summary
      COG0638
      Location:40 → 224
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03763
      Location:43 → 231
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:237 → 270
      Pr_beta_C; Proteasome beta subunits C terminal

    2. NM_001328552.2 → NP_001315481.1  proteasome subunit beta type-10

      Status: VALIDATED

      Source sequence(s)
      CU467646
      UniProtKB/TrEMBL
      A0A8M1PA63, F1QR78
      Related
      ENSDARP00000143228.1, ENSDART00000174325.2
      Conserved Domains (3) summary
      COG0638
      Location:40 → 224
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03763
      Location:43 → 231
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:237 → 270
      Pr_beta_C; Proteasome beta subunits C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      77207693..77218584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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