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    nuf2 UF2 component of NDC80 kinetochore complex [ Danio rerio (zebrafish) ]

    Gene ID: 393280, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nuf2provided by ZNC
    Official Full Name
    UF2 component of NDC80 kinetochore complexprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1121
    See related
    Ensembl:ENSDARG00000034624 AllianceGenome:ZFIN:ZDB-GENE-040426-1121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56708
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within heart development. Predicted to be located in kinetochore and nucleus. Predicted to be part of Ndc80 complex. Is expressed in proliferative region. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nuf2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (429776..438481, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (403276..412020, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene RAB43, member RAS oncogene family Neighboring gene zgc:77375

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, et al. Circulation, 2009 Aug 18. PMID 19652097, Free PMC Article
    2. Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Ramachandran R, et al. Nat Cell Biol, 2012 Oct. PMID 23000964, Free PMC Article
    3. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56708

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Nuf2
    Names
    NDC80 kinetochore complex component NUF2
    NUF2, NDC80 kinetochore complex component, homolog
    cell division cycle-associated protein 1
    un-named hi2769
    unm hi2769

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200310.1 → NP_956604.1  kinetochore protein Nuf2

      See identical proteins and their annotated locations for NP_956604.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050181
      UniProtKB/Swiss-Prot
      Q7ZW63
      Related
      ENSDARP00000040811.5, ENSDART00000040812.7
      Conserved Domains (3) summary
      cl14654
      Location:168 → 392
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      pfam03800
      Location:3 → 145
      Nuf2; Nuf2 family
      cl19219
      Location:325 → 410
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      429776..438481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155671.4 → XP_005155728.1  kinetochore protein Nuf2 isoform X1

      See identical proteins and their annotated locations for XP_005155728.1

      UniProtKB/Swiss-Prot
      Q7ZW63
      Conserved Domains (3) summary
      cl14654
      Location:168 → 392
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      pfam03800
      Location:3 → 145
      Nuf2; Nuf2 family
      cl19219
      Location:325 → 410
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZW63.1 GenPept UniProtKB/Swiss-Prot:Q7ZW63

    Gene LinkOut

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