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    tent2 terminal nucleotidyltransferase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tent2provided by ZNC
    Official Full Name
    terminal nucleotidyltransferase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-536
    See related
    Ensembl:ENSDARG00000099679 AllianceGenome:ZFIN:ZDB-GENE-050522-536
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    papd4; zgc:110560
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA 3'-end processing and negative regulation of miRNA catabolic process. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytoplasm. Is expressed in fin; gonad; gut; head; and muscle. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tent2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (51833334..51847891)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (51186753..51201295)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein DDB_G0271606 Neighboring gene homer scaffold protein 1b Neighboring gene cardiomyopathy associated 5 Neighboring gene metaxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Chang H, et al. Mol Cell, 2018 Apr 5. PMID 29625039
    2. Hen1 is required for oocyte development and piRNA stability in zebrafish. Kamminga LM, et al. EMBO J, 2010 Nov 3. PMID 20859253, Free PMC Article
    3. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans. Vieux KF, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34586415, Free PMC Article
    4. Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression. Her GM, et al. Biochim Biophys Acta, 2013 Jun. PMID 23416188
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110560

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of miRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) RNA polymerase GLD2
    Names
    PAP associated domain containing 4
    PAP-associated domain-containing protein 4
    TUTase2
    NP_001018436.1
    XP_021331832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020600.1 → NP_001018436.1  poly(A) RNA polymerase GLD2

      See identical proteins and their annotated locations for NP_001018436.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095312
      UniProtKB/Swiss-Prot
      Q503I9
      Related
      ENSDARP00000138757.1, ENSDART00000167491.2
      Conserved Domains (2) summary
      cd05402
      Location:182 → 298
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:386 → 440
      PAP_assoc; Cid1 family poly A polymerase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      51833334..51847891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476157.2 → XP_021331832.1  poly(A) RNA polymerase GLD2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PK41
      Conserved Domains (1) summary
      cl27230
      Location:176 → 451
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q503I9.1 GenPept UniProtKB/Swiss-Prot:Q503I9

    Gene LinkOut

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