rad23b RAD23 homolog B, nucleotide excision repair protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rad23bprovided by ZNC
Official Full Name: RAD23 homolog B, nucleotide excision repair proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1487
See related: Ensembl:ENSDARG00000021550 AllianceGenome:ZFIN:ZDB-GENE-040426-1487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65951
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleoplasm. Is expressed in liver. Orthologous to human RAD23B (RAD23 homolog B, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (382400..410449)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (432849..460898)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UV excision repair protein RAD23 homolog B

Names: HR23B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200564.2 → NP_956858.2 UV excision repair protein RAD23 homolog B

Status: VALIDATED

Source sequence(s)

CABZ01079632, CABZ01079633, EH489133

UniProtKB/TrEMBL

A0A2R8PYT0, A0A8M1PD10

Related

ENSDARP00000145115.1, ENSDART00000190785.1

Conserved Domains (5) summary

cd01805
Location:1 → 78

RAD23_N; Ubiquitin-like domain of RAD23

cd14377
Location:159 → 198

UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa

cd14428
Location:337 → 381

UBA2_HR23B; UBA2 domain of UV excision repair protein RAD23 homolog B (HR23B) found in vertebrates

TIGR00601
Location:1 → 379

rad23; UV excision repair protein Rad23

pfam09280
Location:253 → 308

XPC-binding; XPC-binding domain