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    zgc:172295 zgc:172295 [ Danio rerio (zebrafish) ]

    Gene ID: 100136866, updated on 27-Dec-2024

    Summary

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    Official Symbol
    zgc:172295provided by ZNC
    Official Full Name
    zgc:172295provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-72
    See related
    Ensembl:ENSDARG00000053456 AllianceGenome:ZFIN:ZDB-GENE-080204-72
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ATP binding activity and glycerol kinase activity. Predicted to be involved in glycerol catabolic process. Predicted to act upstream of or within glycerol metabolic process; glycerol-3-phosphate metabolic process; and phosphorylation. Predicted to be located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK2 (glycerol kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zgc:172295 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (28722960..28831864, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (27920171..28028516, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495498 Neighboring gene general transcription factor II-I repeat domain-containing protein 2-like Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene protein O-glucosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycerol kinase
    NP_001108056.2
    NP_001418030.1
    NP_001418031.1
    NP_001418032.1
    XP_009289955.1
    XP_009289961.1
    XP_009289973.1
    XP_017210931.1
    XP_068076509.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114584.2 → NP_001108056.2  glycerol kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX901881
      UniProtKB/TrEMBL
      A8WGB0
      Related
      ENSDARP00000124947.1, ENSDART00000148536.2

    2. NM_001431101.1 → NP_001418030.1  glycerol kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX901881
      UniProtKB/TrEMBL
      A0A8M2B6R0, A8WGB0

    3. NM_001431102.1 → NP_001418031.1  glycerol kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX901881
      UniProtKB/TrEMBL
      A0A8M2B6K9, A8WGB0

    4. NM_001431103.1 → NP_001418032.1  glycerol kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX901881
      UniProtKB/TrEMBL
      A0A8M2B752, A8WGB0

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      28722960..28831864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220408.1 → XP_068076509.1  glycerol kinase isoform X5

      UniProtKB/TrEMBL
      A8WGB0

    2. XM_009291686.4 → XP_009289961.1  glycerol kinase isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASS3, A8WGB0
      Conserved Domains (2) summary
      cd07792
      Location:16 → 520
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:16 → 520
      glycerol_kin; glycerol kinase

    3. XM_017355442.3 → XP_017210931.1  glycerol kinase isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z5P5, A8WGB0

    4. XM_009291698.4 → XP_009289973.1  glycerol kinase isoform X4

      UniProtKB/TrEMBL
      A0A8M3AHG1, A8WGB0
      Conserved Domains (2) summary
      cd07792
      Location:16 → 526
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:16 → 526
      glycerol_kin; glycerol kinase

    5. XM_009291680.4 → XP_009289955.1  glycerol kinase isoform X1

      UniProtKB/TrEMBL
      A0A8M3AIJ0, A8WGB0
      Conserved Domains (2) summary
      cd07792
      Location:16 → 526
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:16 → 526
      glycerol_kin; glycerol kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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