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    abhd4 abhydrolase domain containing 4, N-acyl phospholipase B [ Danio rerio (zebrafish) ]

    Gene ID: 550276, updated on 27-Dec-2024

    Summary

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    Official Symbol
    abhd4provided by ZNC
    Official Full Name
    abhydrolase domain containing 4, N-acyl phospholipase Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-83
    See related
    Ensembl:ENSDARG00000102887 AllianceGenome:ZFIN:ZDB-GENE-050417-83
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110267
    Summary
    Predicted to enable hydrolase activity. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abhd4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (51645155..51657111)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (52052351..52064349)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene polymeric immunoglobulin receptor Neighboring gene defender against cell death 1 Neighboring gene transglutaminase 1 like 1 Neighboring gene THAP domain-containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of BPA on zebrafish gonads: Focus on the endocannabinoid system. Forner-Piquer I, et al. Environ Pollut, 2020 Sep. PMID 32417572
    2. The endocannabinoid gene faah2a modulates stress-associated behavior in zebrafish. Krug RG 2nd, et al. PLoS One, 2018. PMID 29304078, Free PMC Article
    3. Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish. Martella A, et al. FASEB J, 2016 Dec. PMID 27623930
    4. Vitamin D deficiency promotes accumulation of bioactive lipids and increased endocannabinoid tone in zebrafish. Knuth MM, et al. J Lipid Res, 2021. PMID 34673019, Free PMC Article
    5. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Forner-Piquer I, et al. Environ Pollut, 2018 Oct. PMID 29793103

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    (Lyso)-N-acylphosphatidylethanolamine lipase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017613.2 → NP_001017613.1  (Lyso)-N-acylphosphatidylethanolamine lipase

      See identical proteins and their annotated locations for NP_001017613.1

      Status: VALIDATED

      Source sequence(s)
      AL929335
      UniProtKB/TrEMBL
      Q568J2
      Related
      ENSDARP00000137303.1, ENSDART00000169600.2
      Conserved Domains (2) summary
      COG0596
      Location:76 → 353
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:77 → 212
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      51645155..51657111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163599.5 → XP_005163656.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAQ5
      Conserved Domains (2) summary
      COG0596
      Location:89 → 366
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:90 → 225
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein Strain
    Heading Accession and Version

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