U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    grik1a glutamate receptor, ionotropic, kainate 1a [ Danio rerio (zebrafish) ]

    Gene ID: 798001, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    grik1aprovided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, kainate 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6502
    See related
    Ensembl:ENSDARG00000069139 AllianceGenome:ZFIN:ZDB-GENE-030131-6502
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grik1; fv36b03; wu:fv36b03
    Summary
    Predicted to enable kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of kainate selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane and presynaptic membrane. Is expressed in dorsal telencephalon. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See grik1a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (25403022..25561811, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (25441309..25600136, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene map3k7 C-terminal like Neighboring gene BTB and CNC homology 1, basic leucine zipper transcription factor 1 b Neighboring gene uncharacterized LOC137496620 Neighboring gene TIAM Rac1 associated GEF 1a Neighboring gene superoxide dismutase 1, soluble

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation. Sheets L. Sci Rep, 2017 Jan 23. PMID 28112265, Free PMC Article
    2. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article
    3. Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). Messina A, et al. Eur J Neurosci, 2021 Jan. PMID 32692463
    4. The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Luo Q, et al. J Fish Biol, 2016 Apr. PMID 26992035
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutamate receptor, ionotropic kainate 1; glutamate receptor ionotropic, kainate 1
    Names
    glutamate receptor, ionotropic, kainate 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      25403022..25561811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223970.1 → XP_068080071.1  glutamate receptor ionotropic, kainate 1 isoform X6

      Related
      ENSDARP00000004703.9, ENSDART00000007778.10

    2. XM_001924003.8 → XP_001924038.3  glutamate receptor ionotropic, kainate 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M1QKZ5, E9QGN5
      Related
      ENSDARP00000118019.1, ENSDART00000147089.3
      Conserved Domains (4) summary
      pfam00060
      Location:562 → 831
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:57 → 398
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:37 → 417
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:431 → 800
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    3. XM_068223968.1 → XP_068080069.1  glutamate receptor ionotropic, kainate 1 isoform X5

    4. XM_068223967.1 → XP_068080068.1  glutamate receptor ionotropic, kainate 1 isoform X5

    5. XM_009305320.4 → XP_009303595.1  glutamate receptor ionotropic, kainate 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3B391
      Conserved Domains (4) summary
      pfam00060
      Location:577 → 846
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:57 → 398
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:37 → 432
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:446 → 815
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    6. XM_009305317.4 → XP_009303592.1  glutamate receptor ionotropic, kainate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3BCZ5
      Conserved Domains (4) summary
      pfam00060
      Location:577 → 846
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:57 → 398
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:37 → 432
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:446 → 815
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    7. XM_009305319.4 → XP_009303594.1  glutamate receptor ionotropic, kainate 1 isoform X2

      See identical proteins and their annotated locations for XP_009303594.1

      UniProtKB/TrEMBL
      A0A8M3AWP9
      Conserved Domains (4) summary
      pfam00060
      Location:577 → 846
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:57 → 398
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:37 → 432
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:446 → 815
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    8. XM_009305318.4 → XP_009303593.1  glutamate receptor ionotropic, kainate 1 isoform X2

      See identical proteins and their annotated locations for XP_009303593.1

      UniProtKB/TrEMBL
      A0A8M3AWP9
      Conserved Domains (4) summary
      pfam00060
      Location:577 → 846
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:57 → 398
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:37 → 432
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:446 → 815
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools