blmh bleomycin hydrolase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: blmhprovided by ZNC
Official Full Name: bleomycin hydrolaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8485
See related: Ensembl:ENSDARG00000025977 AllianceGenome:ZFIN:ZDB-GENE-030131-8485
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66261; wu:fb13c01
Summary: Predicted to enable aminopeptidase activity and cysteine-type peptidase activity. Predicted to be involved in homocysteine catabolic process and response to toxic substance. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm. Orthologous to human BLMH (bleomycin hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (28634580..28677654, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (28701704..28744778, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fl14g11.x1 (e-PCR)
- UniSTS:202005

fb13c01.x1 (e-PCR)
- UniSTS:202891

AI384223 (e-PCR)
- UniSTS:206739

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in homocysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bleomycin hydrolase

NP_956312.1

EC 3.4.22.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200018.1 → NP_956312.1 bleomycin hydrolase

See identical proteins and their annotated locations for NP_956312.1

Status: PROVISIONAL

Source sequence(s)

BC055572

UniProtKB/TrEMBL

Q7SXJ5

Related

ENSDARP00000060254.5, ENSDART00000060255.7

Conserved Domains (1) summary

cd00585
Location:5 → 450

Peptidase_C1B; Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is ...