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    clip2 CAP-GLY domain containing linker protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 556406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clip2provided by ZNC
    Official Full Name
    CAP-GLY domain containing linker protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100727-3
    See related
    Ensembl:ENSDARG00000059596 AllianceGenome:ZFIN:ZDB-GENE-100727-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See clip2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (59397519..59480159)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (58727724..58810457)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uroplakin 3b Neighboring gene RAS p21 protein activator 4 Neighboring gene GTF2I repeat domain containing 1 Neighboring gene deltex 2, E3 ubiquitin ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. Weng JH, et al. Nat Chem Biol, 2013 Oct. PMID 23955365
    2. Neural differentiation modulates the vertebrate brain specific splicing program. Madgwick A, et al. PLoS One, 2015. PMID 25993117, Free PMC Article
    3. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CAP-Gly domain-containing linker protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      59397519..59480159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476654.2 → XP_021332329.1  CAP-Gly domain-containing linker protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4W2, F8W339
      Related
      ENSDARP00000124509.1, ENSDART00000148659.3
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:341 → 994
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_021476655.2 → XP_021332330.1  CAP-Gly domain-containing linker protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B003
      Related
      ENSDARP00000144280.2, ENSDART00000175642.2
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:345 → 886
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_021476656.2 → XP_021332331.1  CAP-Gly domain-containing linker protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BJA6, F1QIN6
      Related
      ENSDARP00000077418.6, ENSDART00000082983.6
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:345 → 869
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394620.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      24484..107124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_679197.9 → XP_684289.2  CAP-Gly domain-containing linker protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4W2, F8W339
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:341 → 994
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_009301892.4 → XP_009300167.1  CAP-Gly domain-containing linker protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B003
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:345 → 886
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_005172017.5 → XP_005172074.1  CAP-Gly domain-containing linker protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BJA6, F1QIN6
      Conserved Domains (2) summary
      pfam01302
      Location:205 → 269
      CAP_GLY; CAP-Gly domain
      cl25732
      Location:345 → 869
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version

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