phc2b polyhomeotic homolog 2b (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: phc2bprovided by ZNC
Official Full Name: polyhomeotic homolog 2b (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1113
See related: Ensembl:ENSDARG00000013224 AllianceGenome:ZFIN:ZDB-GENE-040426-1113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PHC2; zgc:56685
Summary: Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (48137542..48199277)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (48138747..48200517)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: polyhomeotic-like protein 2b

Names: gene name (z): polyhomeotic homolog 2b; polyhomeotic-like 2b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201202.3 → NP_957496.3 polyhomeotic-like protein 2b

Status: VALIDATED

Source sequence(s)

BC139540

UniProtKB/TrEMBL

A0A8M1PJ15, F6P2R0

Related

ENSDARP00000018055.9, ENSDART00000019706.10

Conserved Domains (4) summary

cd09577
Location:822 → 889

SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group

smart00454
Location:823 → 890

SAM; Sterile alpha motif

pfam03153
Location:389 → 554

TFIIA; Transcription factor IIA, alpha/beta subunit

pfam16616
Location:708 → 820

PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

48137542..48199277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005172100.5 → XP_005172157.1 polyhomeotic-like protein 2b isoform X2

See identical proteins and their annotated locations for XP_005172157.1

UniProtKB/TrEMBL

A4QNV8

Conserved Domains (3) summary

cd09577
Location:785 → 852

SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group

smart00454
Location:786 → 853

SAM; Sterile alpha motif

pfam16616
Location:671 → 783

PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
XM_009302666.4 → XP_009300941.1 polyhomeotic-like protein 2b isoform X2

See identical proteins and their annotated locations for XP_009300941.1

UniProtKB/TrEMBL

A4QNV8

Conserved Domains (3) summary

cd09577
Location:785 → 852

SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group

smart00454
Location:786 → 853

SAM; Sterile alpha motif

pfam16616
Location:671 → 783

PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2
XM_021476816.2 → XP_021332491.1 polyhomeotic-like protein 2b isoform X1

UniProtKB/TrEMBL

A0A8M9QA87

Conserved Domains (2) summary

cd09577
Location:802 → 869

SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group

pfam16616
Location:688 → 800

PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2