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    nipa2 NIPA magnesium transporter 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nipa2provided by ZNC
    Official Full Name
    NIPA magnesium transporter 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2134
    See related
    Ensembl:ENSDARG00000055912 AllianceGenome:ZFIN:ZDB-GENE-040426-2134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb72g02; zgc:66088; wu:fb72g02
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Is expressed in dorsal telencephalon and female organism. Orthologous to human NIPA2 (NIPA magnesium transporter 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nipa2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (37733597..37745508, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (37755703..37767614, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 5 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene fibronectin type III domain containing 9 Neighboring gene NIPA magnesium transporter 1 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis. Fongang B, et al. PLoS One, 2016. PMID 27192554, Free PMC Article
    2. Recent assembly of an imprinted domain from non-imprinted components. Rapkins RW, et al. PLoS Genet, 2006 Oct. PMID 17069464, Free PMC Article
    3. Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). Messina A, et al. Eur J Neurosci, 2021 Jan. PMID 32692463
    4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within magnesium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter NIPA2
    Names
    non imprinted in Prader-Willi/Angelman syndrome 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270536.1 → NP_001257465.1  magnesium transporter NIPA2

      See identical proteins and their annotated locations for NP_001257465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EB785012, EH457110, EH488048, EH575890
      UniProtKB/TrEMBL
      A0A8M1PGD1, Q6P694
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. NM_213125.2 → NP_998290.1  magnesium transporter NIPA2

      See identical proteins and their annotated locations for NP_998290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DT074263, EH488048, EH575890, FP085470
      UniProtKB/TrEMBL
      A0A8M1PGD1, Q6P694
      Related
      ENSDARP00000072778.3, ENSDART00000078316.5
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      37733597..37745508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165976.2 → XP_005166033.1  magnesium transporter NIPA2 isoform X2

      See identical proteins and their annotated locations for XP_005166033.1

      UniProtKB/TrEMBL
      A0A8M1PGD1, Q6P694
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. XM_005165975.5 → XP_005166032.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDB1
      Conserved Domains (1) summary
      pfam05653
      Location:57 → 351
      Mg_trans_NIPA; Magnesium transporter NIPA
    Nucleotide Protein Strain
    Heading Accession and Version

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