rack1 receptor for activated C kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rack1provided by ZNC
Official Full Name: receptor for activated C kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-89
See related: Ensembl:ENSDARG00000041619 AllianceGenome:ZFIN:ZDB-GENE-990415-89
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gnb2l1; wu:fb80d08; wu:fk65d12
Summary: Predicted to enable protein kinase C binding activity and ribosome binding activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of gastrulation; and regulation of establishment of cell polarity. Acts upstream of or within angiogenesis and convergent extension involved in gastrulation. Located in cytoplasm. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (6946681..6953678)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (6639954..6646951)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rack1 has a dominant-negative effect on Vangl2 localization and gastrulation.
Title: Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.

Submit: New GeneRIF Correction

General gene information

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Markers

fb80d08.x1 (e-PCR)
- UniSTS:191550

fb12f01.x1 (e-PCR)
- UniSTS:202873

fk65d12.x1 (e-PCR)
- UniSTS:201369

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translational frameshifting	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small ribosomal subunit protein RACK1

Names: RACK; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; receptor for activated protein kinase C; receptor of activated protein kinase C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131444.1 → NP_571519.1 small ribosomal subunit protein RACK1

See identical proteins and their annotated locations for NP_571519.1

Status: PROVISIONAL

Source sequence(s)

AF025330

UniProtKB/Swiss-Prot

O42248

Related

ENSDARP00000061000.3, ENSDART00000061001.5

Conserved Domains (3) summary

COG2319
Location:10 → 310

WD40; WD40 repeat [General function prediction only]

cd00200
Location:8 → 311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:18 → 61

7WD40; WD40 repeat [structural motif]