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    dhtkd1 dehydrogenase E1 and transketolase domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 494076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhtkd1provided by ZNC
    Official Full Name
    dehydrogenase E1 and transketolase domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-44
    See related
    Ensembl:ENSDARG00000016415 AllianceGenome:ZFIN:ZDB-GENE-041212-44
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    E1a; OADC-E1; OADH-E1; zgc:101818
    Summary
    Predicted to enable 2-oxoadipate dehydrogenase activity and thiamine pyrophosphate binding activity. Predicted to act upstream of or within glycolytic process. Predicted to be located in mitochondrion. Is expressed in alar plate midbrain region; eye; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dhtkd1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8031999..8055229, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7907907..7931137, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene upper zone of growth plate and cartilage matrix associated b Neighboring gene calcium/calmodulin-dependent protein kinase 1Db Neighboring gene potassium voltage-gated channel, Shaw-related subfamily, member 1b Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. He S, et al. J Pathol, 2011 Sep. PMID 21744342
    2. Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity. Lin SJ, et al. Genome Med, 2023 Nov 29. PMID 38031187, Free PMC Article
    3. Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease. Kim D, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800130, Free PMC Article
    4. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Wang Y, et al. Funct Integr Genomics, 2011 Mar. PMID 21052758
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2-oxoadipate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-oxoadipate dehydrogenase complex component E1
    Names
    2-oxoadipate dehydrogenase, mitochondrial
    alpha-KADH-E1
    alpha-ketoadipate dehydrogenase
    dehydrogenase E1 and transketolase domain-containing protein 1
    probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
    NP_001008619.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008619.1 → NP_001008619.1  2-oxoadipate dehydrogenase complex component E1

      See identical proteins and their annotated locations for NP_001008619.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086742
      UniProtKB/Swiss-Prot
      Q5PRA2
      Related
      ENSDARP00000025776.6, ENSDART00000003252.8
      Conserved Domains (4) summary
      PRK09404
      Location:43 → 925
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:182 → 455
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:574 → 777
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16870
      Location:785 → 924
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      8031999..8055229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395187.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      603..11759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PRA2.2 GenPept UniProtKB/Swiss-Prot:Q5PRA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.