npr3 natriuretic peptide receptor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: npr3provided by ZNC
Official Full Name: natriuretic peptide receptor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-060531-91
See related: Ensembl:ENSDARG00000035253 AllianceGenome:ZFIN:ZDB-GENE-060531-91
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7138418; zgc:158440; si:dkey-199l1.2
Summary: Predicted to enable natriuretic peptide receptor activity and peptide hormone binding activity. Acts upstream of or within cardiac muscle cell proliferation. Predicted to be located in membrane. Is expressed in several structures, including heart; hypochord; nervous system; neural tube; and renal system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (41260241..41307567, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (40660093..40707479, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified 2 versions of the npr1 gene (npr1a and npr1b); npr1a was mainly expressed in tectal ventricle, brian, heart and retina, whereas npr1b was broadly present in anterior pronephric duct. npr2 mainly expressed in branchial arches and neural tube during embryonic development; npr3 was expressed in pronephric ducts and corpuscle of stannius in zebrafish embryos at 72 hours after fertilization.
Title: The expression of natriuretic peptide receptors in developing zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables natriuretic peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atrial natriuretic peptide receptor 3

Names: natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); natriuretic peptide receptor type C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102673.2 → NP_001096143.2 atrial natriuretic peptide receptor 3 precursor

Status: VALIDATED

Source sequence(s)

BX005419

UniProtKB/TrEMBL

A2RUY7

Related

ENSDARP00000119261.1, ENSDART00000143446.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

41260241..41307567 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165356.5 → XP_005165413.1 atrial natriuretic peptide receptor 3 isoform X1

UniProtKB/TrEMBL

A0A2R8RSJ1, A0A8M2BCR6, A2RUY7

Conserved Domains (3) summary

cd12841
Location:436 → 468

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

pfam01094
Location:46 → 389

ANF_receptor; Receptor family ligand binding region

cl10011
Location:29 → 416

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily