flot1b flotillin 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: flot1bprovided by ZNC
Official Full Name: flotillin 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020430-2
See related: Ensembl:ENSDARG00000037998 AllianceGenome:ZFIN:ZDB-GENE-020430-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb2; cb227; sb:cb2; sb:cb227; reggie-2b; wu:fb53d05
Summary: Predicted to enable protease binding activity. Predicted to be involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; protein kinase C signaling; and regulation of endocytosis. Predicted to be located in endosome and membrane. Predicted to be part of flotillin complex. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including brain; musculature system; paraxial mesoderm; pectoral fin; and pharynx. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (10287588..10316359, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (10396686..10425457, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed that re-2b is transcribed mainly in head mesoderm, in neural crest derivates, and along somite boundaries.
Title: Restricted expression of reggie genes and proteins during early zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb53d05.x1 (e-PCR)
- UniSTS:203304

AI496949 (e-PCR)
- UniSTS:206378

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protease binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase C signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: flotillin-1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201456.1 → NP_958864.1 flotillin-1b

See identical proteins and their annotated locations for NP_958864.1

Status: PROVISIONAL

Source sequence(s)

AY398349

UniProtKB/TrEMBL

A0A8N7V054, Q6TH07

Related

ENSDARP00000094800.4, ENSDART00000104025.5

Conserved Domains (4) summary

COG2268
Location:4 → 423

YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]

cd03399
Location:30 → 175

SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

pfam15975
Location:310 → 385

Flot; Flotillin

cl19107
Location:241 → 346

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily