sirt2 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sirt2provided by ZNC
Official Full Name: sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1028
See related: Ensembl:ENSDARG00000011488 AllianceGenome:ZFIN:ZDB-GENE-030131-1028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55966; zgc:77003; wu:fb57d05
Summary: Predicted to enable NAD+ binding activity; acyltransferase activity, transferring groups other than amino-acyl groups; and protein lysine deacetylase activity. Acts upstream of or within several processes, including negative regulation of angiogenesis; regulation of tubulin deacetylation; and swimming behavior. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Predicted to be active in nucleus. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (6785715..6807965)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (6788613..6810870)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fb57d05.x1 (e-PCR)
- UniSTS:190768

fb57d05 (e-PCR)
- UniSTS:187228

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein demyristoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein depalmitoylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to caloric restriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oligodendrocyte progenitor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swimming behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in juxtaparanode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in meiotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in paranodal junction	ISS Inferred from Sequence or Structural Similarity more info
located_in paranode region of axon	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-2

Names: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; SIR2-like protein 2; regulatory protein SIR2 homolog 2

NP_955890.1

EC 2.3.1.286

XP_009289751.1

EC 2.3.1.286

XP_009289752.1

EC 2.3.1.286

XP_009289753.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199596.1 → NP_955890.1 NAD-dependent protein deacetylase sirtuin-2

See identical proteins and their annotated locations for NP_955890.1

Status: PROVISIONAL

Source sequence(s)

BC045510

UniProtKB/Swiss-Prot

Q7ZVK3

Related

ENSDARP00000003412.6, ENSDART00000013278.7

Conserved Domains (1) summary

cd01408
Location:75 → 328

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

6785715..6807965

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291476.4 → XP_009289751.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1

See identical proteins and their annotated locations for XP_009289751.1

UniProtKB/TrEMBL

A0A8M3ASG7

Conserved Domains (1) summary

cd01408
Location:39 → 292

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
XM_009291478.4 → XP_009289753.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1

See identical proteins and their annotated locations for XP_009289753.1

UniProtKB/TrEMBL

A0A8M3ASG7

Conserved Domains (1) summary

cd01408
Location:39 → 292

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
XM_009291477.4 → XP_009289752.1 NAD-dependent protein deacetylase sirtuin-2 isoform X1

See identical proteins and their annotated locations for XP_009289752.1

UniProtKB/TrEMBL

A0A8M3ASG7

Conserved Domains (1) summary

cd01408
Location:39 → 292

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...