nrf-6 Nose resistant to fluoxetine protein 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nrf-6
Official Full Name: Nose resistant to fluoxetine protein 6
Primary source: WormBase:WBGene00003813
Locus tag: CELE_C08B11.4
See related: AllianceGenome:WB:WBGene00003813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups and lipid binding activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Is expressed in hyp3; hyp5; and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nrf-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (8028953..8032708, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nrf-6 is required in the intestine for sensitivity to fluoxetine-induced nose contraction.
Title: Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08B11.4 (e-PCR)
- UniSTS:307226

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nose resistant to fluoxetine protein 6

NP_495680.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8028953..8032708 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063279.6 → NP_495680.1 Nose resistant to fluoxetine protein 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495680.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09225, Q9U4I8

Conserved Domains (3) summary

smart00703
Location:151 → 288

NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)

COG1835
Location:375 → 790

OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]

pfam01757
Location:375 → 777

Acyl_transf_3; Acyltransferase family