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    ncam1b neural cell adhesion molecule 1b [ Danio rerio (zebrafish) ]

    Gene ID: 114442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncam1bprovided by ZNC
    Official Full Name
    neural cell adhesion molecule 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010822-2
    See related
    Ensembl:ENSDARG00000007220 AllianceGenome:ZFIN:ZDB-GENE-010822-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncam3; zPCAM
    Summary
    Acts upstream of or within axon guidance. Predicted to be located in plasma membrane. Is expressed in nervous system; otic vesicle; posterior neural keel; spinal cord neural rod; and spinal cord neural tube. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ncam1b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (18367307..18574719, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (18432148..18638847, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene odorant receptor, family 91, subfamily A, member 3 Neighboring gene zinc finger and BTB domain containing 16b Neighboring gene cell adhesion molecule 1b Neighboring gene uncharacterized LOC103908826 Neighboring gene uncharacterized LOC137487738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish. Koide T, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19497864, Free PMC Article
    2. Sublethal effects of waterborne uranium exposures on the zebrafish brain: transcriptional responses and alterations of the olfactory bulb ultrastructure. Lerebours A, et al. Environ Sci Technol, 2010 Feb 15. PMID 20088580
    3. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system. Langhauser M, et al. Glycobiology, 2012 Feb. PMID 21890892
    4. Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system. Miyasaka N, et al. Development, 2005 Mar. PMID 15716341
    5. Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system. Miyasaka N, et al. Development, 2007 Jul. PMID 17537794

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system.
      Title: Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 1b
    Names
    neural cell adhesion molecule 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131831.1 → NP_571906.1  neural cell adhesion molecule 1b precursor

      See identical proteins and their annotated locations for NP_571906.1

      Status: PROVISIONAL

      Source sequence(s)
      AY029401
      UniProtKB/TrEMBL
      A0A8M2B466, Q90YM2
      Related
      ENSDARP00000114314.1, ENSDART00000142010.3
      Conserved Domains (6) summary
      cd00096
      Location:426 → 497
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:505 → 598
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      18367307..18574719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213451.1 → XP_068069552.1  neural cell adhesion molecule 1b isoform X13

      UniProtKB/TrEMBL
      A0A8M3ASL0

    2. XM_005157411.5 → XP_005157468.1  neural cell adhesion molecule 1b isoform X9

      UniProtKB/TrEMBL
      A0A8M2B493, A0A8M3AH87
      Conserved Domains (7) summary
      cd00096
      Location:416 → 487
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:495 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam05387
      Location:780 → 984
      Chorion_3; Chorion family 3
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    3. XM_068213447.1 → XP_068069548.1  neural cell adhesion molecule 1b isoform X7

      UniProtKB/TrEMBL
      A0A8M2B3I6

    4. XM_005157410.5 → XP_005157467.1  neural cell adhesion molecule 1b isoform X8

      UniProtKB/TrEMBL
      A0A8M2B3Q1, A0A8M2B466
      Conserved Domains (7) summary
      cd00096
      Location:426 → 497
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:505 → 598
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam05387
      Location:790 → 994
      Chorion_3; Chorion family 3
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    5. XM_068213446.1 → XP_068069547.1  neural cell adhesion molecule 1b isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z9Y9

    6. XM_068213444.1 → XP_068069545.1  neural cell adhesion molecule 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M2B488

    7. XM_068213445.1 → XP_068069546.1  neural cell adhesion molecule 1b isoform X4

      UniProtKB/TrEMBL
      A0A8M3APN8

    8. XM_068213450.1 → XP_068069551.1  neural cell adhesion molecule 1b isoform X12

      UniProtKB/TrEMBL
      A0A8M3ASL0

    9. XM_005157408.5 → XP_005157465.1  neural cell adhesion molecule 1b isoform X6

      UniProtKB/TrEMBL
      A0A8M2B3H7, A0A8M2B466
      Conserved Domains (7) summary
      cd00096
      Location:434 → 505
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:513 → 606
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam05387
      Location:798 → 1002
      Chorion_3; Chorion family 3
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    10. XM_009291551.4 → XP_009289826.1  neural cell adhesion molecule 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M3AID4, A0A8M3ASK5
      Conserved Domains (7) summary
      cd00096
      Location:434 → 505
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:513 → 606
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam05387
      Location:809 → 1013
      Chorion_3; Chorion family 3
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    11. XM_068213449.1 → XP_068069550.1  neural cell adhesion molecule 1b isoform X11

      UniProtKB/TrEMBL
      A0A8M3ASL0

    12. XM_068213448.1 → XP_068069549.1  neural cell adhesion molecule 1b isoform X10

      UniProtKB/TrEMBL
      A0A8M3AID9

    13. XM_009291549.4 → XP_009289824.1  neural cell adhesion molecule 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3P6, A0A8M3B0V3
      Conserved Domains (7) summary
      cd00096
      Location:434 → 505
      Ig; Immunoglobulin domain
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:121 → 205
      IG_like; Immunoglobulin like
      cd00063
      Location:513 → 606
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam05387
      Location:814 → 1018
      Chorion_3; Chorion family 3
      pfam07679
      Location:212 → 298
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:208 → 301
      Ig; Immunoglobulin domain

    14. XM_068213452.1 → XP_068069553.1  neural cell adhesion molecule 1b isoform X14

      UniProtKB/TrEMBL
      A0A8M3APP3
    Nucleotide Protein
    Heading Accession and Version

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