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    dcp1a decapping mRNA 1A [ Danio rerio (zebrafish) ]

    Gene ID: 360153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dcp1aprovided by ZNC
    Official Full Name
    decapping mRNA 1Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030723-5
    See related
    Ensembl:ENSDARG00000100136 AllianceGenome:ZFIN:ZDB-GENE-030723-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SMIF; mitc1
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of catalytic activity. Predicted to be active in P-body. Orthologous to human DCP1A (decapping mRNA 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dcp1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53388032..53399708)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53008644..53020320)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1a Neighboring gene zgc:171572 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit, b Neighboring gene choline dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. Bai RY, et al. Nat Cell Biol, 2002 Mar. PMID 11836524
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-decapping enzyme 1A
    Names
    MAD homolog 4 interacting transcription coactivator 1
    Smad4-interacting transcriptional co-activator
    decapping enzyme
    NP_878313.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182893.2 → NP_878313.2  mRNA-decapping enzyme 1A

      See identical proteins and their annotated locations for NP_878313.2

      Status: PROVISIONAL

      Source sequence(s)
      BC044477
      UniProtKB/TrEMBL
      Q803I0
      Related
      ENSDARP00000132177.1, ENSDART00000171920.3
      Conserved Domains (2) summary
      cd09804
      Location:6 → 126
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
      pfam16741
      Location:396 → 438
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      53388032..53399708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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