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    il17rd interleukin 17 receptor D [ Danio rerio (zebrafish) ]

    Gene ID: 171474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    il17rdprovided by ZNC
    Official Full Name
    interleukin 17 receptor Dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020320-5
    See related
    Ensembl:ENSDARG00000098359 AllianceGenome:ZFIN:ZDB-GENE-020320-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sef; cb208; id:ibd2875; id:ibd5059; zgc:136328
    Summary
    Predicted to enable interleukin-17 receptor activity. Acts upstream of or within dorsal/ventral pattern formation; negative regulation of MAPK cascade; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and neural rod. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 18 with or without anosmia. Orthologous to human IL17RD (interleukin 17 receptor D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See il17rd in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (42641469..42719359)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42352132..42429269)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene HESX homeobox 1 Neighboring gene si:ch73-106k19.2 Neighboring gene zgc:194981 Neighboring gene tudor domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb. Harduf H, et al. Dev Dyn, 2005 Jun. PMID 15844098
    2. Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Fürthauer M, et al. Nat Cell Biol, 2002 Feb. PMID 11802165
    3. Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1. Ryzhakov G, et al. J Mol Evol, 2011 Jun. PMID 21643828
    4. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee Y, et al. Development, 2005 Dec. PMID 16251209
    5. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Asai Y, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754885, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC136328

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-17 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-17 receptor D
    Names
    IL-17 receptor D
    IL-17RD
    similar expression to FGF genes protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328553.2 → NP_001315482.2  interleukin-17 receptor D isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      CU459094, CU459189
      UniProtKB/Swiss-Prot
      Q4VBV6, Q8QHJ6, Q8QHJ9
      UniProtKB/TrEMBL
      A0A0R4INF1, B3DKQ2
      Related
      ENSDARP00000136390.3, ENSDART00000169938.3
      Conserved Domains (3) summary
      pfam08357
      Location:354 → 517
      SEFIR; SEFIR domain
      pfam16742
      Location:46 → 167
      IL17R_D_N; N-terminus of interleukin 17 receptor D
      cl01930
      Location:234 → 279
      DUF2141; Uncharacterized protein conserved in bacteria (DUF2141)

    2. NM_153660.3 → NP_705946.3  interleukin-17 receptor D isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CU459094, CU459189
      UniProtKB/Swiss-Prot
      Q4VBV6, Q8QHJ6, Q8QHJ9
      Related
      ENSDARP00000140479.2, ENSDART00000172641.3
      Conserved Domains (3) summary
      pfam08357
      Location:355 → 518
      SEFIR; SEFIR domain
      pfam16742
      Location:47 → 168
      IL17R_D_N; N-terminus of interleukin 17 receptor D
      cl01930
      Location:235 → 280
      DUF2141; Uncharacterized protein conserved in bacteria (DUF2141)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      42641469..42719359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QHJ9.2 GenPept UniProtKB/Swiss-Prot:Q8QHJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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