mettl13 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mettl13provided by ZNC
Official Full Name: methyltransferase 13, eEF1A lysine and N-terminal methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-60
See related: Ensembl:ENSDARG00000010905 AllianceGenome:ZFIN:ZDB-GENE-060929-60
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: eef1aknmt; zgc:152769; si:dkey-19f21.2
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to act upstream of or within methylation. Is expressed in brain; heart; inner ear; and swim bladder. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (14927728..14941080, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (15031748..15045100, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: eEF1A lysine and N-terminal methyltransferase

Names: methyltransferase like 13; methyltransferase-like protein 13

NP_001038234.3

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044769.4 → NP_001038234.3 eEF1A lysine and N-terminal methyltransferase

Status: VALIDATED

Source sequence(s)

BX470128

UniProtKB/Swiss-Prot

A5WVX1, Q567H9

UniProtKB/TrEMBL

A0A8M1N9K6, G1K2I9

Related

ENSDARP00000026819.9, ENSDART00000021394.11

Conserved Domains (2) summary

cl09608
Location:125 → 238

Cas7_I-E; CRISPR/Cas system-associated RAMP superfamily protein Cas7

cl17173
Location:53 → 155

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...