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    mkln1 muskelin 1, intracellular mediator containing kelch motifs [ Danio rerio (zebrafish) ]

    Gene ID: 325217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mkln1provided by ZNC
    Official Full Name
    muskelin 1, intracellular mediator containing kelch motifsprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3942
    See related
    Ensembl:ENSDARG00000025576 AllianceGenome:ZFIN:ZDB-GENE-030131-3942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc60a07; wu:fc60a07
    Summary
    Predicted to be involved in anatomical structure morphogenesis. Predicted to be active in cytoplasm. Orthologous to human MKLN1 (muskelin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mkln1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (11695982..11730753)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (11697133..11731904)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene microRNA 29b-2 Neighboring gene uncharacterized LOC100536865 Neighboring gene uncharacterized LOC137491523 Neighboring gene podocalyxin-like Neighboring gene uncharacterized LOC100536913 Neighboring gene uncharacterized LOC137491524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association. Prag S, et al. Biochem J, 2004 Jul 15. PMID 15084145, Free PMC Article
    2. Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish. Mishima Y, et al. Genes Cells, 2017 Jul. PMID 28557307
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    muskelin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212694.1 → NP_997859.1  muskelin

      See identical proteins and their annotated locations for NP_997859.1

      Status: PROVISIONAL

      Source sequence(s)
      AF418017
      UniProtKB/TrEMBL
      B2GSV0, Q8AYJ5
      Related
      ENSDARP00000113321.2, ENSDART00000137736.4
      Conserved Domains (5) summary
      PLN02153
      Location:301 → 495
      PLN02153; epithiospecifier protein
      sd00038
      Location:265 → 316
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:450 → 494
      Kelch_1; Kelch motif
      pfam06588
      Location:6 → 201
      Muskelin_N; Muskelin N-terminus
      pfam13415
      Location:276 → 328
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      11695982..11730753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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